ClusterCS is datacenter agnostic, your VPS or Dedicated Server can be managed by ClusterCS regardless of your infrastructure provider. All you need is to connect the server with an user that has root permissions.

The Supported OS versions are : CentOS 6/7, RHEL 6/7, Amazon AMI & Linux 2.

It is preferred that you use a clean-install because connecting the Control Panel to the server will overwrite the configuration files for services (for which we would recommend not using a server that is in production at the moment).